The cost of a personal assistant will be more than a virtual assistant and you will be responsible for employing them. But you will be receiving 100% of their time and whilst this requires a certain amount of administration on your part there are companies such as Staff Tax in the UK for private staff who can help with payroll, employment contracts and pensions. For an idea of how much a PA would expect to be paid you can read more here.
All businesses accept that when starting out they will at some point require additional support. Most often the first consideration is employment of additional staff. Although this can often be daunting especially with all the red tape surrounding employment and legal requirements. More expense can also be driven into the business with a need for larger office space, equipment such as computers, phone lines etc. This is all before the employee has even started. New staff can also mean re-focusing time and effort inwards rather than developing the business and potentially decreasing revenue at a time when increases are most needed.
If you are developing a business that is online, you should check out You can hire talented assistants for most types of tasks. I hired world-class designers and programmers to build my iTunes app business at low cost. oDesk takes care of the tax forms and payments to your assistants. Pretty nifty and you only pay for work that gets done. You could likely set up a local virtual assistant through their system if you need help at your office.
Even with the right tools and adequate planning, virtual teams in the workplace can pose unique challenges for global companies of all sizes. An experienced talent development firm can help companies navigate the trials that come with virtual collaboration across cultural boundaries. Choose to work with a firm with a validated inventory in the market and a proven record for success.

My team has been distributed evenly between in-office and remote workers from the start. As we've grown, one of the most critical dynamics we've seen develop is the need to transcribe all discussions to accommodate remote co-workers in varying time zones. This has created an impeccable auditing system for when we've needed to pull up information instantly to tackle problems, disagreements or work opportunities. - George Georgallides, XO

I doubt many companies like or prefer that employees work from home. We allow the policy in order to be able to attract employees who would otherwise go elsewhere. We are heavy users of Slack, Confluence and other collaboration tools that make working at home more productive, but they cannot replace the serendipitous interactions that occur while hanging out by the nitro-coffee keg. - Manuel Vellon, Level 11

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